Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H₂O₂

Figure 4

Effect of HSC-MVs on AST, ALT, and LDH leakage of APAP or H₂O₂-treated BRL-3A and HL-7702. (a) AST, ALT, and LDH leakage of APAP or H₂O₂-treated BRL-3A cocultured with . (b) AST, ALT, and LDH leakage of APAP or H₂O₂-treated HL-7702 cocultured with . versus vehicle, APAP; versus vehicle, H₂O₂; ^#, ^## versus treatment control, APAP; , versus treatment control, H₂O₂; versus L-HSC-MVs, APAP; , versus L-HSC-MVs, H₂O₂; , versus M-HSC-MVs, APAP; , vs M-HSC-MVs, ; /group; ~ represents < 0.05 versus L-HSC-MVs, APAP.