Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis

Table 1

Effects of GHRH and its analogues.

	GHRH	GHRH agonists	GHRH antagonists	Differences between GHRH and analogues
Promote GH secretion	++; [25–28]	++; [29, 30]	—	Quantitative
Cell proliferation	/	+; [31, 32]	—	Qualitative and quantitative
Cardiac protection (reduce infarct size, ameliorate cell apoptosis, and restore heart function)	/	+; [33–36]	—	Qualitative and quantitative
Antitumor effect (suppress tumor cell proliferation and angiogenesis)	—	—	+++; [23, 24, 37–42]	Qualitative and quantitative

Note: +, ++, and +++ represent positive effect: + for mild effect, ++ for moderate, and +++ for significant and strong effect; — represents suppressive effect; / represents no effect.