Stromal Derived Factor-1/CXCR4 Axis Involved in Bone Marrow Mesenchymal Stem Cells Recruitment to Injured Liver

Figure 5

BMSCs migration in injured liver inhibited by anti-CXCR4 antibody and AMD3100. (a) The fluorescent intensity of normal rats after Dir-labeled BMSCs injection; (b) the fluorescent intensity of dissected normal livers after Dir-labeled BMSCs injection; (c) the fluorescent intensity of rats with TAA induced liver injury after Dir-labeled BMSCs injection; (d) the fluorescent intensity of dissected TAA injured livers after Dir-labeled BMSCs injection; (e) the fluorescent intensity of rats with TAA induced liver injury after Dir-labeled BMSCs and AMD3100 injection at the same time; (f) the fluorescent intensity of dissected injured livers after Dir-labeled BMSCs and AMD3100 injection at the same time; (g) the fluorescent intensity of rats with TAA induced liver injury after anti-CXCR4 antibody pretreated and Dir-labeled BMSCs injection; (h) the fluorescent intensity of dissected injured livers after anti-CXCR4 antibody pretreated and Dir-labeled BMSCs injection; (i) Dir-labeled BMSCs before injection were as positive control; (j) rats without cell injection were as negative control; (k) the fluorescent intensity value and fold changes of the dissected livers of each group; the differences were statistically significant.