Improvement of Liver Transplantation Outcome by Heme Oxygenase-1-Transduced Bone Marrow Mesenchymal Stem Cells in Rats

Figure 6

Proportion of Tregs in recipient splenocytes. (A) Normal saline group; (B) HO-1 group; (C) BMMSCs group; (D) HO-1/MSCs group. Percentages of CD4+CD25+Foxp3+ cells in recipient spleens were measured by flow cytometry. (a) Scatter plots on POD 1, 7, and 14 showing that the percentage of Tregs was higher in HO-1/MSC-treated rats than in the control groups. (b) Histogram showing percentages of Tregs on POD 3, 5, 7, 10, 14, and 28. The number of Tregs in the HO-1/MSCs group first increased and then decreased but peaked on POD 14 and were significantly higher than those of other groups on POD 3, 5, 7, 10, 14, and 28 ().

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