Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury

Figure 2

RNA-Seq transcriptome analysis showing increased transcription of Bmp4 transcripts in OPCs and newly formed oligodendrocytes in postnatal mice compared to other CNS cells. This is unique to Bmp4; closely related BMP2 does not show similar levels of increased transcription in oligodendroglial lineage cells compared to other CNS cells. Additionally, increased Bmp4 transcription does not appear to be counteracted by concomitant transcriptional increases expression of BMP inhibitors, such as noggin and chordin. The functional relevance of increased Bmp4 transcription by OPCs and immature oligodendrocytes remains to be clarified (FPKM = fragments per kilobase of transcript per million mapped reads.).