Skeletal Muscle-Derived Stem/Progenitor Cells: A Potential Strategy for the Treatment of Acute Kidney Injury

Figure 2

Morphology and proliferation analysis of MDSPCs and BM-MSCs. (a) The BM-MSCs during the first day of culture appeared as round-shaped cells. After 3-4 days, the adherent cells became spindle-shaped (BM-MSCs, passage 1). BM-MSCs were passaged after reaching 65–70% confluence (BM-MSCs, passages 3, 6). MDSPCs appeared as round, triangular, or spindle-shaped (MDSPCs, passage 1). MDSPCs were passaged after reaching 65–70% confluence (MDSPCs, passages 3, 6). (b) MDSPCs had significantly higher proliferation rate () in comparison to BM-MSCs, as reflected by the average population doubling time. The average PDT of MDSPCs was hours, while BM-MSCs exhibited a PDT of hours. , significant difference.

(a)

(b)