Skeletal Muscle-Derived Stem/Progenitor Cells: A Potential Strategy for the Treatment of Acute Kidney Injury

Figure 6

MDSPCs impact on morphological recovery after AKI and their presence in the damaged renal tissue during the period of 2 weeks. Gentamicin injections at 80 mg/kg for 7 consecutive days caused typical aminoglycoside-induced AKI, including the tubular necrosis (yellow arrow heads), loss of brush border in renal tubules (green arrow heads), and tubular dilatation (green both-way arrows) ((a); GM (D8) and GM + MDSPCs (D8)), represented by the renal injury score of and , respectively (b). MDSPCs injection attenuated renal tubular damage ((a); GM + MDSPCs (D21)) and significantly lowered renal injury score to , compared with the injury score of in GM group after 21 days ((b); ). PKH-26-labeled MDSPCs were detected within the renal cortex, localized primarily in the renal tubules and the interstitial compartment of the kidney 7 and 14 days after the MDSPCs administration ((c); yellow arrows). , significant difference.

(a)

(b)

(c)