A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice

Figure 5

Histomorphological analysis of reepidermalization during skin healing in mice. (a, d) Histological analysis of wounds showed significantly increased length of the wound epithelial tongue in mice of treatment group Wnt-CM, as compared to the MSC-CM and DMEM treatment groups on postinjury days 3 and 5. (b, e) The epidermis thickness of the wounds treated with Wnt-CM, MSC-CM, or DMEM in mice on postinjury day 14. (c) The number of regeneration hair follicles in a wound. The data are presented as mean ± SEM, ; . The arrow indicates hair follicle regeneration. GT, granulation tissue; WE, wound epithelium; Epi, epidermis; Der, dermis. The scale bar in panels (a), (b), and (c) is 100 μm.