Research Article
Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology
Figure 3
Total and differential cell counts, as well as protein content, in bronchoalveolar lavage fluid in pulmonary ARDS (ARDSp) (a) and extrapulmonary ARDS (ARDSexp) (b) animals. ARDS was induced by administration of Escherichia coli lipopolysaccharide intratracheally (ARDSp) or intraperitoneally (ARDSexp). Control mice (C) received saline solution intratracheally (Cp) or intraperitoneally (Cexp). After 24 h, ARDSp and ARDSexp animals were further randomized to receive saline (50 μL, SAL), bone marrow-derived MSCs (105, 50 μL), or EVs (105, 50 μL), stimulated or not with serum (MSCs, EVs, MSC serum, and EV serum) obtained from ARDSp or ARDSexp animals. Values were expressed as deviation of 6 animals per group. Significantly different from the corresponding C group (). Significantly different from the corresponding ARDS group ().
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