Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity

Figure 10

Shikonin increased β1/β2/β5 and decreased β1i/β2i/β5i, PSME1/PSME2/PSME3 expression levels. Immunohistochemical staining of (a) β1/β2/β5, (b) β1i/β2i/β5i, and (c) PSME1/PSME2/PSME3 of Shikonin-treated glioma subcutaneous implantation model.

(a)

(b)

(c)