METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients

Figure 7

The expression of m6A-related protein METTL3 in pPDLSCs was lower than that in hPDLSCs. METTL3 promoted the expression and stability of downstream lncRNA CUTALP by regulating m6A modification. LncRNA CUTALP increased the expression of Runx2 through competitive binding of miR-30b-3p, thereby promoting osteogenic differentiation. METTL3/lncRNA CUTALP/miR-30b-3p/Runx2 is a regulatory network for osteogenic differentiation of pPDLSCs.