Effects of Extracellular Vesicles Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells on Cell Immunity in Nonobese Mice

<div>Effects of HucMSC-EVs on T lymphocyte subsets and Th1/Th2 ratio of splenocytes in NOD mice. The proportion of CD4<sup>+</sup> T lymphocytes and Th1/Th2 ratio (IFN-<i>γ</i> as a marker of Th1 cells, IL-4 as a marker of Th2 cells) was detected by flow cytometry: (a) HucMSC-EVs inhibited the proliferation of CD4<sup>+</sup> T lymphocyte subsets; (b) HucMSC-EVs decreased the proportion of IFN-<i>γ</i>; and (c) HucMSC-EVs increased the proportion of IL-4. <span class="nowrap"><svg height="10.7395pt" id="M18" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 53.0975 10.7395" width="53.0975pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,2.179,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 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Stem Cells International

fig6

Figure 6

Figure 6: Effects of Extracellular Vesicles Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells on Cell Immunity in Nonobese Mice 