TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis

Figure 5

Poly(I : C) treated ADSCs with favorable effects in NF-κB signaling transduction in taurocholate-induced pancreatitis mice: (a, b) the protein expression of IKB and IKKα/β in the pancreas (n = 3), (c) nuclear translocation of NF-κB in ADSCs treatment pancreatitis mouse pancreas (n = 6, Bar = 50 μm), (d) the proinflammatory cytokines gene expression of IL-1β, IL-6, and TNF-α in the pancreas (n = 6), (e) the levels of IL-1β, IL-6, and TNF-α in pancreas tissue (n = 8), and (f, g) the protein expression of Bax, cleaved-caspase 3, Bcl2, and Bcl-xL in the pancreas (n = 3). Data were represented as mean ± SD, the post hoc Tukey correction was performed after ANOVA was used for comparison of more than two groups. , .

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