Research Article
TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis
Figure 6
The favorable anti-inflammatory effects of poly(I : C) treated ADSCs on NF-κB transduction depended on regulating macrophage: (a) diagram of the model for coculture of ADSCs and pancreatic acinar cell or macrophage, (b) the amylase activity in cocultured acinar cells (n = 8), (c, d) the protein expression of IKB and IKKα/β in cocultured acinar cells (n = 3), (e) the amylase activity in the acinar cell cocultured with macrophage in cell-to-cell contract (n = 8), (f) the levels of IL-1β, IL-6, and TNF-α in supernatant from the lower chamber in different cocultured models (n = 8) and (g, h) the protein expression of IKB and IKKα/β in acinar cells from pancreatic acinar cells cocultured with macrophage in cell-to-cell contract (n = 3). The data were represented as mean ± SD, the post hoc Tukey correction was performed after ANOVA was used for the comparison of more than two groups. , .
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