Review Article

Neuroimaging and Neurocognitive Correlates of Aggression and Violence in Schizophrenia

Table 1

Results of relevant neuropsychological studies in aggressive schizophrenic patients.

AuthorsSample characteristicsResults of relevant neuropsychological studies

Lafayette et al. [58] 96 schizophrenic patients (34 violent arrests, 23 nonviolent arrest, 39 no arrest)No significant differences between the groups in the WAIS, Wisconsin Card Sortig Test, Trail Making Test, Verbal fluency Test, Stroop Test, American National Adult Reading Test

Krakowski et al. [59]32 transiently violent schizophrenic patients, 27 persistently violent schizophrenic patientsNo difference in the average performance and verbal IQ on the WAIS-R

Wong et al. [60]20 male schizophrenic patients who had committed several violent offenses, 19 male schizophrenic patients who had committed only 1 violent offense. No difference in the WAIS performance between the groups

Silver et al. [61]35 violent patients with chronic schizophrenia or schizoaffective disorder, 35 nonviolent schizophrenic patients, 46 healthy controlsNo difference between violent and nonviolent schizophrenic patients in the cognitive test battery

Fullam and Dolan [62]33 violent and 49 nonviolent male forensic inpatients with schizophreniaNo difference between violent and nonviolent schizophrenic patients in the cognitive test battery but lower IQ scores in the violent schizophrenic patients

Roy et al. [63] 20 chronic, treatment-resistant inpatients with schizophrenia; (11 violent and 9 low-violent men) Violent patients outperformed nonviolent patients on the verbal IQ, digit symbol test, block design

Lapierre et al. [64] 31 schizophrenic men (outpatients) and 30 healthy control subjectsHigher level of violence in the more cognitively functional individuals on the Wisconsin Card Sorting Test and Controlled Oral Word Association test

Rasmussen [65]13 inpatients aggressive schizophrenic patients from a maximum security psychiatric unit, 13 nonaggressive schizophrenic patients, 13 healthy controls Violent schizophrenic patients outperformed nonviolent schizophrenic patients on the Trail Making
Test and showed faster reaction time on all reaction time tests but more failed inhibitions on the Go-NoGo test

Krakowski et al. [66] 28 high, 27 low, and 34 nonviolent schizophrenic patientsHigh-violent patients were more impaired on the Benton Visual Retention Test, digit symbol test, block design and had lower performance IQ scores on the WAIS-R

Adams et al. [67] 37 male schizophrenic patientsHistory of violent arrests but not inpatients violence was associated with impairment on the Luria Nebraska neuropsychological battery

Barkataki et al. [68] 13 individuals with a history of serious violence and a diagnosis of antisocial personality disorder, 13 individuals with a history of violence and schizophrenia, 15 individuals with schizophrenia without a history of violent behaviour, 15 healthy control subjectsViolent schizophrenic patients had a higher number of errors in the Wisconsin Card Sorting Test

Foster et al. [69] 1 year prospective study of aggression in 23 male forensic psychiatric inpatientsScores on Stroop Color Word Tasks, Judgment of Line Orientation Test, Symbol Digit Modalities Test only significantly predicted frequency but not severity

Krakowski et al. [70] 33 psychiatric violent inpatients versus 69 nonviolent psychiatric inpatients History of community violence was related to impairment on some Wisconsin Card Sorting Subtests, finger tapping, Perdue pegboard

WAIS-R: Wechsler Adult Intelligence Scale-revised.