Role of Angiopoietin/Tie2 in Critical Illness: Promising Biomarker, Disease Mediator, and Therapeutic Target?
Figure 2
Tie2 activation via the synthetic pegylated 7-mer “HHHRHSF” termed Vasculotide (VT) improves ssurvival in experimental murine sepis. (a) C57BL6 mice were pretreated with 500 ng VT () or PBS (control, ) 7 h prior to injection of a 70% lethal LPS dose. VT improved survival by 41.4% (). (b) Male Tie-2 heterozygous (Tie-2 +/−) mice were pretreated with 500 ng VT or PBS 7 h prior to injection of LPS. Survival was indistinguishable () excluding unspecific off target effects of VT. (Modified after: [50].)
