Processing of the amyloid precursor protein (APP). The precursor protein is acted upon by either alpha- or beta-secretase, followed by cleavage by gamma-secretase. Cleavage by beta-secretase allows formation of beta-amyloid (shown in black) by gamma-secretase, while alpha-secretase prevents beta-amyloid formation. Locations of the alpha-, beta-, and gamma-secretase cut sites are shown, along with APP mutations and the names that are associated with certain mutations.
