Review Article
Chronic Heart Failure: We Are Fighting the Battle, but Are We Winning the War?
Table 1
Reductions in mortality observed in randomized, controlled trials evaluating drug or device therapies in patients with chronic heart failure that were powered for all-cause mortality and resulted in Level of Evidence A recommendations in clinical guidelines.
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If the patient is unable to tolerate an ACE inhibitor, an angiotensin receptor blocker may be prescribed. ACE inhibitor: angiotensin converting enzyme inhibitor. HF: heart failure. LVEF: left ventricular ejection fraction. LBBB: left bundle branch block. CONSENSUS: cooperative north scandinavian enalapril survival study. SOLVD-T: studies of left ventricular dysfunction-treatment. CIBIS-II: cardiac insufficiency bisoprolol study II. MERIT-HF: metoprolol CR/XL randomised intervention trial in congestive heart failure. COPERNICUS: carvedilol prospective randomized cumulative survival. RALES: randomized aldactone evaluation study. EMPHASIS HF: eplerenone in mild patients hospitalization and survival study in heart failure. MADIT-II: multicenter automatic defibrillator implantation trial II. SCD-HeFT: sudden cardiac death in heart failure trial (SCD-HeFT). COMPANION: comparison of medical therapy, pacing, and defibrillation in heart failure. CARE-HF: cardiac resynchronization in heart failure study. RAFT: resynchronization/defibrillation for ambulatory heart failure trial. |