Direct Acting Antivirals for the Treatment of Chronic Viral Hepatitis

Figure 1

The closed covalent circular DNA of HBV depicted in linear form and showing positions of the direct repeats (DR) 1 and 2, and the polyadenylation signal (An). The open readings frames encoding for the surface (S), polymerase (P), X and Precore/core proteins are shown above, whilst the RNA transcripts are shown below the cccDNA. The various RNA transcripts terminate at the common polyadenylation signal.