Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging
Figure 3
Average age trajectories (±s.e.) of diastolic blood pressure (“DBP”) for female and male carriers (“e4”) and noncarriers (“no e4”) of the APOE e4 allele who survived until different ages (“LS” denotes life span); f(t, G) are age trajectories for the long-lived groups fitted by cubic polynomials (used as physiological “norms” in the genetic stochastic process model, see the text). Data source: Framingham Heart Study (original cohort).
