Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging
Figure 7
Application of the genetic stochastic process model to longitudinal measurements of diastolic blood pressure (“DBP”) and data on mortality for males in the Framingham Heart Study (original cohort): Estimates of the logarithm of the baseline hazard (a), the multiplier in the quadratic part of the hazard (b), the adaptive capacity (the absolute value of the feedback coefficient) (c), and the mean allostatic trajectory (d) for carriers (“e4”) and noncarriers (“No e4”) of the APOE e4 allele.
