The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response

Figure 5

Domain structure of yeast Ssa1 Hsp70. The N-terminal half of the protein formS the nucleotide binding domain, and the C-terminal half is the substrate binding domain. The cysteine residues are indicated with yellow bars and their positions are shown in red.