Clinical Study
Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer
Table 2
Missense mutations in Caucasian and African American cases and controls.
| Nucleotide position | Amino acid | Conservation index |
Grantham value | Allelic index | Controls () | Control frequency | Cases () | Case frequency | Count | % | Count | % |
| C5911T | A3V | 5/61 = 8% | 64 | 0.2 | 4 | 2.1 | 3 | 0.6 | G5913A | D4N | 8/61 = 13% | 23 | 0.4 | 0 | 0.0 | 1 | 0.2 | A5935G | N11S | 61/61 = 100% | 46 | Unique | 0 | 0.0 | 1 | 0.2 | G5949A | G16X | 61/61 = 100% | — | Unique | 0 | 0.0 | 1 | 0.2 | G5973A | A24T | 60/61 = 98% | 58 | 0.04 | 0 | 0.0 | 1 | 0.2 | A6040G | N46S | 8/61 = 13% | 46 | 0.1 | 0 | 0.0 | 1 | 0.2 | G6081A | A60T | 60/61 = 98% | 58 | Unique | 0 | 0.0 | 1 | 0.2 | T6124C | M74T | 60/61 = 98% | 81 | Unique | 0 | 0.0 | 1 | 0.2 | G6150A | V83I | 58/61 = 95% | 29 | 0.2 | 8 | 4.2 | 5 | 1.0 | T6253C | M117T | 44/61 = 72% | 81 | 0.9 | 7 | 3.7 | 7 | 1.5 | G6261A | A120T | 61/61 = 100% | 58 | 0.5 | 1 | 0.5 | 8 | 1.7 | G6267A | A122T | 56/61 = 92% | 58 | 0.1 | 0 | 0.0 | 2 | 0.4 | G6285A | V128I | 61/61 = 100% | 29 | 0.04 | 0 | 0.0 | 1 | 0.2 | C6340T | T146I | 45/61 = 74% | 89 | 0.1 | 0 | 0.0 | 2 | 0.4 | G6366A | V155I | 42/61 = 69% | 29 | 0.3 | 1 | 0.5 | 1 | 0.2 | G6480A | V193I | 58/61 = 95% | 29 | 0.1 | 0 | 0.0 | 3 | 0.6 | A6663G | I254V | 59/61 = 97% | 29 | 0.2 | 7 | 3.7 | 14 | 2.9 | A6891G | S330G | 7/61 = 11% | 56 | 0.04 | 0 | 0.0 | 1 | 0.2 | G6924T | A341S | 61/61 = 100% | 99 | Unique | 0 | 0.0 | 1 | 0.2 | G7041A | V380I | 61/61 = 100% | 29 | 0.04 | 0 | 0.0 | 1 | 0.2 | T7080C | F393L | 60/61 = 98% | 22 | 0.04 | 0 | 0.0 | 2 | 0.4 | A7083G | I395V | 13/61 = 21% | 29 | 0.04 | 0 | 0.0 | 1 | 0.2 | A7146G | T415A | 15/61 = 25% | 58 | 3.1 | 36 | 19.0 | 69 | 14.3 | C7147T | T415I⋯V* | 15/61 = 25% | 89⋯69* | Unique | 0 | 0.0 | 2 | 0.4 | A7158G | I419V | 9/61 = 15% | 29 | 0.1 | 0 | 0.0 | 3 | 0.6 | A7299G | M466V | 39/61 = 64% | 21 | 0.07 | 1 | 0.5 | 0 | 0.0 | T7354C | M484T | 11/61 = 18% | 81 | Unique | 1 | 0.5 | 0 | 0.0 | A7305C | M468L | 60/61 = 98% | 95 | Unique | 0 | 0.0 | 1 | 0.2 | T7389C | Y496H | 15/61 = 25% | 83 | 2 | 25 | 13.2 | 57 | 11.8 | G7444A | X514K | — | — | 0.4 | 1 | 0.5 | 1 | 0.2 |
| | | | | | 92 | | 192 | |
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enotes double AA change because the patient also had a mutation at the previous AA position A7146G.
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