Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer

Table 2

Missense mutations in Caucasian and African American cases and controls.

Nucleotide position	Amino acid	Conservation index	Grantham value	Allelic index	Controls (𝑛=189)	Control frequency	Cases (𝑛=482)	Case frequency
					Count	%	Count	%
C5911T	A3V	5/61 = 8%	64	0.2	4	2.1	3	0.6
G5913A	D4N	8/61 = 13%	23	0.4	0	0.0	1	0.2
A5935G	N11S	61/61 = 100%	46	Unique	0	0.0	1	0.2
G5949A	G16X	61/61 = 100%	—	Unique	0	0.0	1	0.2
G5973A	A24T	60/61 = 98%	58	0.04	0	0.0	1	0.2
A6040G	N46S	8/61 = 13%	46	0.1	0	0.0	1	0.2
G6081A	A60T	60/61 = 98%	58	Unique	0	0.0	1	0.2
T6124C	M74T	60/61 = 98%	81	Unique	0	0.0	1	0.2
G6150A	V83I	58/61 = 95%	29	0.2	8	4.2	5	1.0
T6253C	M117T	44/61 = 72%	81	0.9	7	3.7	7	1.5
G6261A	A120T	61/61 = 100%	58	0.5	1	0.5	8	1.7
G6267A	A122T	56/61 = 92%	58	0.1	0	0.0	2	0.4
G6285A	V128I	61/61 = 100%	29	0.04	0	0.0	1	0.2
C6340T	T146I	45/61 = 74%	89	0.1	0	0.0	2	0.4
G6366A	V155I	42/61 = 69%	29	0.3	1	0.5	1	0.2
G6480A	V193I	58/61 = 95%	29	0.1	0	0.0	3	0.6
A6663G	I254V	59/61 = 97%	29	0.2	7	3.7	14	2.9
A6891G	S330G	7/61 = 11%	56	0.04	0	0.0	1	0.2
G6924T	A341S	61/61 = 100%	99	Unique	0	0.0	1	0.2
G7041A	V380I	61/61 = 100%	29	0.04	0	0.0	1	0.2
T7080C	F393L	60/61 = 98%	22	0.04	0	0.0	2	0.4
A7083G	I395V	13/61 = 21%	29	0.04	0	0.0	1	0.2
A7146G	T415A	15/61 = 25%	58	3.1	36	19.0	69	14.3
C7147T	T415I⋯V^*	15/61 = 25%	89⋯69^*	Unique	0	0.0	2	0.4
A7158G	I419V	9/61 = 15%	29	0.1	0	0.0	3	0.6
A7299G	M466V	39/61 = 64%	21	0.07	1	0.5	0	0.0
T7354C	M484T	11/61 = 18%	81	Unique	1	0.5	0	0.0
A7305C	M468L	60/61 = 98%	95	Unique	0	0.0	1	0.2
T7389C	Y496H	15/61 = 25%	83	2	25	13.2	57	11.8
G7444A	X514K	—	—	0.4	1	0.5	1	0.2
					92		192

^∗Denotes double AA change because the patient also had a mutation at the previous AA position A7146G.