The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target

Figure 1

Domains and splice isoforms of tau. Exons 2, 3 and 10 are alternatively spliced. Inclusion/exclusion of exons 2 and 3 are denoted as 0N, 1N, or 2N. Inclusion/exclusion of exon 10, encoding the second of four possible repeated microtubule binding domains, are denoted as 3R or 4R.