|
| MicroRNA | Misregulation in AML | Relevant targets | Effects |
|
| miR-17-92 | Overexpressed in AML with MLL rearrangements [75] | AML1 [55], BIM [93], PTEN [91], p21 [94] | Counteracts monocytopoiesis
[55, 57] |
|
| miR-29b | Downregulated in AML with MLL rearrangements and deleted in AML with loss of chromosome 7q [44, 84] | MCL1 [84], CDK6 [84], IGFR [84], JAK2 [84], DNMT3a [84], DNMT3b [84] | Induces apoptosis and inhibits proliferation of AML cells [44] |
|
| miR-125b | Upregulated in t(2;11) AML [79] | LIN28A [83] | Inibits myeloid differentiation in AML cells and CD34+ progenitor cells [79, 80]
Induces leukemia when overexpressed in mouse bone marrow [81, 82] |
|
| miR-146a | Downregulated in CN-AML [22] | NF-κB [60] | miR-146a knock-out mice present myeloid malignancies [59, 60] |
|
| miR-155 | Upregulated in FLT3-ITD AML [107, 108] | C/EBPb [110] | Produces a myeloproliferative disorder when overexpressed in mouse hematopoietic stem cells [109] |
|
| miR-181 | Upregulated in AML with CEBPA mutations [71] | p27 [54] | Counteracts monocytopoiesis [54] |
|
| miR-196b | Overexpressed in AML with MLL rearrangements [74–78] | HOXB8 [114] | Induces proliferation and survival capacity when overexpressed in bone marrow progenitor cells
[78] |
|
| miR-223 | Dowmregulated in t(8;21) AML [33] | E2F1 [30], MEF2C [35], NFIA [26] | Induces granulocytc differentiation in AML cells [26, 30, 33]
miR-223 knock-out mice present altered granulocyte immunological function [35] |
|
| miR-342 | Downregulated in t(15;17) AML (APL) [40, 44] | n.d. | Induces granulocyitc differentiation in AML cells [38] |
|
