Table 1: Cochaperones.

NameFunctionConserved domainRole in cancerAssociated proteinsReference

Hsp70

JDPSubstrate selectionJSupp[101105]
HspBP1Nucleotide exchangeSupp[9699]
Bag1Nucleotide exchangeBAG, UBLOnc[92]
Bag3Nucleotide exchangeBAG, WWOncHspB8[90, 91, 93]
HopAdaptorTPR OncTDB proteins[107109]

Hsp90

Sgt1Substrate selectionCHORDHsp70[116119]
P23ATPase inhibitorp23Onc[112115]
Aha1ATPase inhibitorAha1Onc[131, 132]
Cdc37ATPase inhibitorHsp90 bdOncKinases[120129]
HopAdaptorTPROncTDB[107109]
Cyp40ImmunophilinTPR, PPiaseTDB[32, 134]
FKBP1ImmunophilinTPR, PPiaseOncTDB[135, 136]
FKBP2ImmunophilinTPR, PPiaseOncTDB, dynein[134, 137, 138]
PP5Protein phosphataseTPRTDB[139147]
TTC4Adaptor, replicationTPRSuppTDB, Myst, MOF[148153]
TTC5Adaptor, transcriptionTPRTDB, p300[88, 154157]
XAP2Nuclear receptorsTPRTDB[158161]