Review Article
Spontaneous and Procedural Plaque Embolisation in Native Coronary Arteries: Pathophysiology, Diagnosis, and Prevention
Table 2
Main results from clinical trials about manual thrombus aspiration compared to conventional PCI.
| Study | Year | Device | PTS | Endpoint | FUP | Results | References |
| REMEDIA | 2005 | Diver CE | 99 | ST resolution ≥ 70% MBG ≥ 2 MCE index WMSI | X 6 months 6 months | ↑ ↑ ↓ ↓ | [101, 106] |
| DEAR MI | 2006 | Pronto | 148 | ST resolution ≥ 70% MBG ≥ 2 | X | ↑ ↑ | [100] |
| De Luca et al. | 2006 | Diver CE | 76 | ST resolution ≥ 70% MBG ≥ 2 LV remodeling MACE | X 6 months 6 months | ↑ ↑ ↓ ↔ | [102] |
| Chevalier et al. | 2008 | Export | 249 | ST resolution ≥ 70% MBG ≥ 2 | X | ↑ ↑ | [105] |
| Chao et al. | 2008 | Export | 74 | Delta TIMI Delta MBG | X | ↑ ↑ | [103] |
| TAPAS | 2008 | Export | 1071 | MBG 0/1 Cardiac death reinfarction | X 1 year | ↓ ↓ | [98, 109] |
| Lipiecki et al. | 2009 | Export | 44 | Infarct size (SPECT) LV fraction (SPECT) | X | ↔ ↔ | [104] |
| Liictro et al. | 2009 | Export | 111 | ST resolution ≥ 70% MBG ≥ 2 MCE index WMSI | X 6 months | ↑ ↑ ↓ ↓ | [107] |
| EXPIRA | 2009 | Export | 175 | ST resolution ≥ 70% MBG ≥ 2 MVO at CMR | X 3 months | ↑ ↑ ↓ | [108] |
| PIHRATE | 2010 | Diver CE | 196 | ST resolution ≥ 70% MBG = 3 | X | ↑ ↑ | [99] |
| TASTE | 2013 | Eliminate Expert Pronto | 7244 | All-cause mortality Recurrent MI Stent thrombosis | 30 days | ↔ ↔ ↔ | [110] |
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CMR: cardiac magnetic resonance; FUP: follow-up; LV: left ventricular; MBG: myocardial blush grade; MCE: myocardial contrast echocardiography; MVO: microvascular obstruction; PTS: patients; SPECT: single photon emission computed tomography; WMSI: wall motion score index.
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