Table 2: Main results from clinical trials about manual thrombus aspiration compared to conventional PCI.

StudyYearDevicePTSEndpointFUPResultsReferences

REMEDIA2005Diver CE99ST resolution ≥ 70%
MBG ≥ 2
MCE index
WMSI
X
6 months
6 months



[101, 106]

DEAR MI2006Pronto148ST resolution ≥ 70%
MBG ≥ 2
X
[100]

De Luca et al.2006Diver CE76ST resolution ≥ 70%
MBG ≥ 2
LV remodeling
MACE
X
6 months
6 months



[102]

Chevalier et al.2008Export249ST resolution ≥ 70%
MBG ≥ 2
X
[105]

Chao et al.2008Export74Delta TIMI
Delta MBG
X
[103]

TAPAS2008Export1071MBG 0/1
Cardiac death reinfarction
X
1 year

[98, 109]

Lipiecki et al.2009Export44Infarct size (SPECT)
LV fraction (SPECT)
X
[104]

Liictro et al.2009Export111ST resolution ≥ 70%
MBG ≥ 2
MCE index
WMSI
X
6 months



[107]

EXPIRA2009Export175ST resolution ≥ 70%
MBG ≥ 2
MVO at CMR
X
3 months


[108]

PIHRATE2010Diver CE196ST resolution ≥ 70%
MBG = 3
X
[99]

TASTE2013Eliminate
Expert Pronto
7244All-cause mortality
Recurrent MI
Stent thrombosis
30 days

[110]

CMR: cardiac magnetic resonance; FUP: follow-up; LV: left ventricular; MBG: myocardial blush grade; MCE: myocardial contrast echocardiography; MVO: microvascular obstruction; PTS: patients; SPECT: single photon emission computed tomography; WMSI: wall motion score index.