About this Journal Submit a Manuscript Table of Contents
Scientifica
Volume 2013 (2013), Article ID 457982, 5 pages
http://dx.doi.org/10.1155/2013/457982
Review Article

Bullous Skin Diseases: Classical Types of Autoimmune Diseases

Laboratory of Clinical Immunology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands

Received 31 October 2012; Accepted 12 December 2012

Academic Editors: A. Amedei, G. Lesinski, and U. Tursen

Copyright © 2013 Jan Damoiseaux. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and/or oral mucosa in combination with circulating and deposited autoantibodies reactive with (hemi)desmosomes. Koch’s postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch’s postulates are fulfilled, and, therefore, these bullous skin diseases are to be considered classical autoimmune diseases within the wide and expanding spectrum of autoimmune diseases.