Bullous Skin Diseases: Classical Types of Autoimmune Diseases

Table 1

Clinical and laboratory characteristics of bullous skin diseases.

Disease	Skin	Mucosa	Nikolsky sign*	DIF**	IIF	Autoantigen
Bullous pemphigoid	+	−	II	BMZ	BMZ	BP180
Pemphigus vulgaris	+/−	+	I	CWP	CWP	Dsg3 +/− Dsg1
Pemphigus foliaceus	+	−	I	CWP	CWP	Dsg1

∗Nikolsky sign I is the classical Nikolsky sign; the alternative Nikolsky sign II was originally described as the Asboe-Hansen sign.
**BMZ: basement membrane zone; BP: bullous pemphigoid; CWP: chicken-wire pattern; DIF: direct immunofluorescence; Dsg: desmoglein; IIF: indirect immunofluorescence.