Protein Machineries Involved in the Attachment of Heme to Cytochrome c: Protein Structures and Molecular Mechanisms

Figure 4

Schematic representation of System III. A single protein (HCCS) associated to the mitochondrial inner membrane is required for Cyt c maturation. The translocation process of heme (shown in red) is unknown. System III is found in the mitochondria of fungi (e.g., S. cerevisiae), vertebrates (e.g., human), and invertebrates (e.g., C. elegans, Drosophila).