Gene name Protein name Other names Chromosome location Sequence length MW (Da) First methionine removed Polymorphisms Reference 20S subunits PSMA1
C2, Pro-
,
_sc, nu, Pros30, p30k, Pre5, HC2, PSC2 11p15.1 263 29556 No rs17850016 (G37V) [36 , 37 ] PSMA2
C3, Pro-
,
_sc, Pre8, Prs4, Y7, HC3, PSC3, Lmpc3 7p14.1 233 25767 Yes (L110V) [38 , 39 ] PSMA3
C8, Pro-
,
_sc, Pre10, Prs1, C1, Prc1, HC8, PSC8 14q23 254 28302 Yes [40 ] PSMA4
C9, Pro-
,
_sc, Pre9, Prs5, Y13, HC9, PSC9 15q25.1 261 29484 No [41 ] PSMA5
Zeta, Pro-
,
_sc, Pip2, Doa5,
Pup2
1p13 241 26411 No [42 ] PSMA6
Iota, Pro-
,
_sc, Pros27, pre27k, C7, Prs2, Y8, Scl1 14q13 246 27399 No rs1048990 (-8C-G), rs15434 (A233S) [37 , 43 , 44 ] PSMA7
C6, Pro-
,
_sc, XAPC-7, Pre6 20q13.33 248 27887 No 335C-A (A112D) [38 , 45 ] PSMA8 — PSMA7L 18q11.2 256 28530
No [46 ] PSMB1
C5, gamma, Psc5, Pre7, Prs3, Pts1 6q27 241 26489 No rs12717 (P11A), rs10541 (I208N) [36 , 47 ] PSMB2
C7, Pre1, C11, C7-I, HC7-I 1p34.2 201 22836 No [48 ] PSMB3
C10, theta, Pup3, C10-II 17q12 204 22818 Yes rs4907 (M34L) [48 , 49 ] PSMB4
N3, beta, Pros26, HsN3, Pre4, Rn3, Lmp3 1q21 264/219* 29204/24392* No rs1804241 (M95I), rs4603 (I234T) [46 , 48 –51 ] PSMB5
X, epsilon, LmpX, MB1, Pre2, Doa3, Prg1 14q11.2 263/204* 28480/22458* No rs11543947 (R24C) [44 , 48 , 52 ] PSMB6
Y, delta, LmpY, Pre3, Lmp19 17p13 239/205* 25358/21904* Yes rs2304974 (P107A) [44 , 52 ] PSMB7
Z, alpha, Pup1, Mmc14 9q34.11-q34.12 277/234* 29965/25295* No rs4574 (V39A) [36 , 53 ] PSMB8
Lmp7, Psmb5i, Ring10, Y2, C13, Mc13 6p21.3 276/204* 30354/22660* No rs114772012 (G8R), (PGH30-32RPD), rs2071543 (Q49K), rs17220206 (T74S), (T75M), (G201V) [46 , 54 –57 ] PSMB9
Lmp2, Psmb6i, Ring12 6p21.3 219/199* 23264/21276* No rs35100697 (G9E), rs241419 (V32I), rs17587 (R60H), rs17213861 (R173C) [58 , 59 ] PSMB10
MECL-1, Lmp10 16q22.1 273/234* 28936/24648* No [60 ] PSMB11
beta5i-like, beta5t 14q11.2 300/251* 32530/27232* No rs34457782 (G49S) [34 ] 19S proteasome PSMC1 Rpt2 S4, Yhs4, Yta5, P26s4 14q32.11 440 49185 Yes [38 ] PSMC2 Rpt1 S7, Mss1, Yta3, Cim5, Nbla10058 7q22.1-q22.3 432 48503 Yes [61 ] PSMC3 Rpt5 S6a, S6′, p50, Tbp1, Yta1, Sata 11p11.2 439 49204 No [61 ] PSMC4 Rpt3 S6b, S6, Mip224, Tbp7, Yta2, Ynt1, Cip21 19q13.11-q13.13 418 47336 No [61 ] PSMC5 Rpt6 S8, p45, Trip1, Sug1, Cim3, Crl3, Tbpy, Tby1 17q23.3 405 45495 Yes (R60Q), rs11543211 (R258W) [39 , 44 ] PSMC6 Rpt4 S10b, p42, Sug2, Prs10, Pcs1, Crl13, CADP44, P44 14q22.1 389 44173 No [38 ] PSMD1 Rpn2 S1, p112, Sen3 2q37.1 953 105836 No [60 ] PSMD2 Rpn1 S2, p97, Trap2, Hrd2, Nas1, Rpd1, Protein 55.11 3q27.1 908 100200 No rs11545172 (A176T), rs11545169 (E313D), rs17856236 (N724Y) [44 , 61 ] PSMD3 Rpn3 S3, p58, Sun2, P91a, Tstap91a 17q21.1 534 60978 No [60 ] PSMD4 Rpn10 S5a, ASF1, Mcb1, Sun1 1q21.3 377 40737 No [61 ] PSMD5 — S5b, KIAA0072 9q34.11 503 56065 Yes rs2297575 (E21G), rs17282618 (L72H) [60 , 61 ] PSMD6 Rpn7 S10a, SGA-113M, p44S10, p42A, PFAAP4, KIAA0107 3p21.1 389 45531 No [60 ] PSMD7 Rpn8 S12, p40, Mov34L 16q23-q24 324 37025 No [62 ] PSMD8 Rpn12 S14, p31, Nin1 19q13.2 350 39612 No [60 ] PSMD9 — S15, p27 12q24.31-q24.32 223 24682 No rs2230681 (V17A), rs2291116 (T74I), rs1177573 (R134W), rs1177573 (E197G) [50 , 63 –65 ] PSMD10 Gank-yrin p28, p28(GANK) Xq22.3 226 24428 No [38 ] PSMD11 Rpn6 S9, p44.5, Nas4 17q11.2 421 47333 Yes [38 ] PSMD12 Rpn5 p55, Nas5 17q24.3 455 52773 Yes rs2230680 (V358A) [60 ] PSMD13 Rpn9 S11, p40.5, Les1, Nas7 11p15.5 376 42945 No rs1045288 (N13S), rs28927679 (S150L), rs1794108 (G204E), rs1794109 (L205F) [36 , 66 –68 ] PSMD14 Rpn11 Poh1, Mpr1, Mad1, Pad1, PAD1 homolog 1, 2q24.2 310 34577 No [38 ] Proteasome activators PSME1 PA
PA28A, IFI5111, 1S REG-alpha 14q11.2 249 28723 No rs1803830 (S55N), rs14930 (T244K) [48 , 52 ] PSME2 PA
PA28B, 1S REG-beta 14q12 238 27270 Yes rs7146672 (H89P) [48 , 60 , 69 ] PSME3 PA
PA28G 17q21.31 253 29375 Yes [60 , 70 ] PSME4 PA200 KIAA0077, 1S REG-gamma 2p16.2 1843 211334 No rs2302878 (I872V), rs805408 (S1371T), rs35903236 (T1825A) [38 , 44 ] Proteasome inhibitor PSMF1 PI31 20p13 271 29817 No rs1803415 (F36C), rs2235587 (H176R) [60 , 71 ]
