Table 5: This is a summary of studies comparing the oral antibiotic bowel preparation plus systemic antibiotics versus systemic antibiotics alone in elective colon surgery. Only studies with a total study population of 100 or more patients are included. The oral antibiotics used are indicated.

Author, (year)Combined antibiotics receivedOral and IV antibioticsIV Antibiotics onlyComments
SWINo. of patientsSWINo. of patients

Kaiser et al. (1983) [77]Neo-erythro2 (3%)637 (12.5%)56 ; for operations > 4 hrs in duration
Lau et al. (1988) [78]Neo-erythro3 (5%)655 (7.5%)67No statistical difference
Coppa and Eng (1988) [79]Neo-erythro9 (5%)16915 (11%)141
Reynolds et al. (1989) [80]Neo-metro9 (8%)10726 (12%)223No statistical difference
Khubchandani et al. (1989) [81]Neo-erythro5 (9%)5514 (30%)47 ( with Yates’ correction)
Taylor and Lindsay (1994) [82]Ciprofloxacin17 (11%)15930 (18%)168 ; no published evidence to support ciprofloxacin.
McArdle et al. (1995) [83]Ciprofloxacin8 (10%)8220 (23%)87 ; no published evidence to support ciprofloxacin.
Lewis (2002) [101]Neo-metro5 (5%)10417 (16.5%)103