The Prevention of Surgical Site Infection in Elective Colon Surgery

Table 5

This is a summary of studies comparing the oral antibiotic bowel preparation plus systemic antibiotics versus systemic antibiotics alone in elective colon surgery. Only studies with a total study population of 100 or more patients are included. The oral antibiotics used are indicated.

Author, (year)	Combined antibiotics received	Oral and IV antibiotics		IV Antibiotics only		Comments
		SWI	No. of patients	SWI	No. of patients
Kaiser et al. (1983) [77]	Neo-erythro	2 (3%)	63	7 (12.5%)	56	𝑃<0.06; 𝑃<0.05 for operations > 4 hrs in duration
Lau et al. (1988) [78]	Neo-erythro	3 (5%)	65	5 (7.5%)	67	No statistical difference
Coppa and Eng (1988) [79]	Neo-erythro	9 (5%)	169	15 (11%)	141	𝑃<0.11
Reynolds et al. (1989) [80]	Neo-metro	9 (8%)	107	26 (12%)	223	No statistical difference
Khubchandani et al. (1989) [81]	Neo-erythro	5 (9%)	55	14 (30%)	47	𝑃<0.03 (𝑃<0.05 with Yates’ correction)
Taylor and Lindsay (1994) [82]	Ciprofloxacin	17 (11%)	159	30 (18%)	168	𝑃<0.11; no published evidence to support ciprofloxacin.
McArdle et al. (1995) [83]	Ciprofloxacin	8 (10%)	82	20 (23%)	87	𝑃<0.05; no published evidence to support ciprofloxacin.
Lewis (2002) [101]	Neo-metro	5 (5%)	104	17 (16.5%)	103	𝑃<0.01