Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer

<table>General strategy to optimize NK cell immunotherapy. A three-tiered approach to comprehensively modify NK cells for optimal antitumor responses. (1) Enhance NK cell recognition and triggering while providing enhanced specificity, (2) augment functional status using cytokines, immunomodulatory drugs, or prior viral infection, and (3) remove inhibitory signals that include inhibitory KIR/NKG2A/PD-1, block Treg mediated regulation, and block NK cell suppressive cytokines.</table>

Scientifica

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Figure 1

Figure 1: Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer 