Does B Cell Receptor Signaling in Chronic Lymphocytic Leukaemia Cells Differ from That in Other B Cell Types?
Figure 3
Possible roles of ZAP70, RhoH, and HS1 in BCR signaling in CLL cells. Schematic showing the potential role of ZAP70 as a scaffolding protein for Lck, RhoH, talin, and HS1 at the immunological synapse formed when the BCR is cross-linked on CLL cells. HS1 becomes hyperphosphorylated by Lyn, Syk, and Lck and plays a role with RhoH in regulating cytoskeletal remodeling.
