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Scientifica
Volume 2014 (2014), Article ID 481016, 14 pages
http://dx.doi.org/10.1155/2014/481016
Review Article

Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population

Department of Virology, National Centre of Microbiology, Instituto de Salud Carlos III, Road Majadahonda-Pozuelo, Km2, Majadahonda, 28220 Madrid, Spain

Received 7 November 2013; Accepted 25 December 2013; Published 10 February 2014

Academic Editors: S. Bofill-Mas, M. Ciccozzi, M. T. Shata, and F. R. Spilki

Copyright © 2014 José-Manuel Echevarría. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. T. Shata and U. Navaneethan, “The mystery of hepatitis E seroprevalence in developed countries: is there subclinical infection due to hepatitis E virus?” Clinical Infectious Diseases, vol. 47, no. 8, pp. 1032–1034, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. F. Drexler, A. Seelen, V. M. Corman, et al., “Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae,” Journal of Virology, vol. 86, pp. 9134–9147, 2012.
  3. W. Batts, S. Yun, R. Hedrick, and J. Winton, “A novel member of the family Hepeviridae from cutthroat trout (Oncorhynchus clarkii),” Virus Research, vol. 158, no. 1-2, pp. 116–123, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. D. B. Smith, M. A. Purdy, and P. Simmonds, “Genetic variability and the classification of hepatitis E virus,” Journal of Virology, vol. 87, pp. 4161–4169, 2013.
  5. A. B. Labrique, K. Zaman, Z. Hossain et al., “Population seroprevalence of hepatitis E virus antibodies in rural Bangladesh,” The American Journal of Tropical Medicine and Hygiene, vol. 81, no. 5, pp. 875–881, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Dong, X. Dai, J.-S. Shao, K. Hu, and J.-H. Meng, “Identification of genetic diversity of hepatitis E virus (HEV) and determination of the seroprevalence of HEV in eastern China,” Archives of Virology, vol. 152, no. 4, pp. 739–746, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. K. Stoszek, M. Abdel-Hamid, D. A. Saleh et al., “High prevalence of hepatitis E antibodies in pregnant Egyptian women,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 2, pp. 95–101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Verhoef, M. Koopmans, E. Duizer, J. Bakker, J. Reimerink, and W. van Pelt, “Seroprevalence of hepatitis E antibodies and risk profile of HEV seropositivity in The Netherlands, 2006-2007,” Epidemiology and Infection, vol. 140, pp. 1838–1847, 2012.
  9. S. Ijaz, A. J. Vyse, D. Morgan, R. G. Pebody, R. S. Tedder, and D. Brown, “Indigenous hepatitis E virus infection in England: more common than it seems,” Journal of Clinical Virology, vol. 44, no. 4, pp. 272–276, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. H. Kuniholm, R. H. Pureell, G. M. McQuillan, R. E. Engle, A. Wasley, and K. E. Nelson, “Epidemiology of hepatitis E virus in the United States: results from the third national health and nutrition examination survey, 1988–1994,” Journal of Infectious Diseases, vol. 200, no. 1, pp. 48–56, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. R. P. Holla, I. Ahmad, z. Ahmad, and S. Jameel, “Molecular virology of hepatitis E virus,” Seminars in Liver Disease, vol. 33, pp. 3–14, 2013. View at Scopus
  12. F. De Ory, I. Pachón, J. M. Echevarría, and R. Ramírez, “Seroepidemiological study of herpes simplex virus in the female population in the autonomous region of Madrid, Spain,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 18, no. 9, pp. 678–680, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. D. T. Fleming, G. M. Mcquillan, R. E. Johnson et al., “Herpes simplex virus type 2 in the United States, 1976 to 1994,” The New England Journal of Medicine, vol. 337, no. 16, pp. 1105–1111, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. R. A. Aggarwal, “Hepatitis E: clinical presentation in disease-endemic areas and diagnosis,” Seminars in Liver Disease, vol. 33, pp. 30–40, 2013.
  15. H. R. Dalton, W. Stableforth, S. Hazeldine et al., “Autochthonous hepatitis E in Southwest England: a comparison with hepatitis A,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 27, no. 7, pp. 579–585, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Said, S. Ijaz, G. Kafatos et al., “Hepatitis E outbreak on cruise ship,” Emerging Infectious Diseases, vol. 15, no. 11, pp. 1738–1744, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Kamar, L. Rostaing, and J. Izopet, “Hepatitis E virus infection in immunossupressed patients: natural history and therapy,” Seminars in Liver Disease, vol. 33, pp. 62–70, 2013.
  18. B. Kmush, T. Wierzba, L. Krain, K. Nelson, and A. B. Labrique, “Epidemiology of hepatitis E in low- and middle-income countries of Asia and Africa,” Seminars in Liver Disease, vol. 33, pp. 15–29, 2013.
  19. A. Jeblaoui, S. Haim-Boukobza, E. Marchadier, C. Mokhtari, and A.-M. Roque-Afonso, “Genotype 4 hepatitis E virus in France: an autochthonous infection with a more severe presentation,” Clinical Infectious Diseases, vol. 57, no. 4, pp. e122–e126, 2013. View at Publisher · View at Google Scholar
  20. M. Herremans, H. Vennema, J. Bakker et al., “Swine-like hepatitis E viruses are a cause of unexplained hepatitis in the Netherlands,” Journal of Viral Hepatitis, vol. 14, no. 2, pp. 140–146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Kantala, L. Maunula, C.-H. von Bonsdorff, J. Peltomaa, and M. Lappalainen, “Hepatitis E virus in patients with unexplained hepatitis in Finland,” Journal of Clinical Virology, vol. 45, no. 2, pp. 109–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Reuter, D. Fodor, P. Forgách, A. Kátai, and G. Szucs, “Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary,” Journal of Clinical Virology, vol. 44, no. 4, pp. 277–281, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Echevarría, M. Fogeda, and A. Avellón, “Diagnosis of acute hepatitis E by antibody and molecular testing: a study on 277 suspected cases,” Journal of Clinical Virology, vol. 50, pp. 69–71, 2011.
  24. A. Candido, S. Taffon, P. Chionne, et al., “Diagnosis of HEV infection by serological and real-time PCR assays: a study on acute non-A-C hepatitis collected from 2004 to 2010 in Italy,” BMC Research Notes, vol. 5, pp. 297–303, 2012.
  25. J. Drobeniuc, T. Greene-Montfort, N.-T. Le, et al., “Laboratory-based surveillance for hepatitis E virus infection, United States, 2005–2012,” Emerging Infectious Diseases, vol. 19, pp. 218–222, 2013.
  26. M. S. Munné, N. R. Altabert, S. N. Vladimirsky et al., “Identifications of polyphyletic variants in acute hepatitis suggest an underdiagnosed circulation of hepatitis E virus in Argentina,” Journal of Clinical Virology, vol. 52, no. 2, pp. 138–141, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. M. C. Dell'Amico, A. Cavallo, J. L. Gonzales et al., “Hepatitis E virus genotype 3 in humans and swine, Bolivia,” Emerging Infectious Diseases, vol. 17, no. 8, pp. 1488–1490, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. D. R. Lopes dos Santos, L. L. Lewis-Ximenez, M. F. M. da Silva, P. S. F. de Sousa, A. M. C. Gaspar, and M. A. Pinto, “First report of a human autochthonous hepatitis E virus infection in Brazil,” Journal of Clinical Virology, vol. 47, no. 3, pp. 276–279, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Drobeniuc, R. Novak, L. Ganova-Raeva et al., “Genetic diversity of the epidemic hepatitis E virus in Mexico, 1986–1987,” in Proceedings of the 13th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD '09), Washington, DC, USA, Abstract. P161, March 2009.
  30. C. Gutiérrez, D. Sánchez, M. C. Villalba, et al., “Molecular characterization of hepatitis E virus in patients with acute hepatitis in Venezuela,” Journal of Medical Virology, vol. 84, pp. 1025–1029, 2012.
  31. S. Mirazo, N. Ramos, J. C. Russi, G. Gagliano, and J. Arbiza, “Detection and molecular characterization of sporadic cases of acute human hepatitis E virus infection in Uruguay,” Archives of Virology, vol. 156, no. 8, pp. 1451–1454, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. M. C. Montalvo, L. A. R. Lay, V. Chandra et al., “Hepatitis E virus genotype 1, Cuba,” Emerging Infectious Diseases, vol. 14, no. 8, pp. 1320–1322, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Crossan, P. J. Baker, J. Craft, Y. Takeuchi, H. R. Dalton, and L. Scobie, “Hepatitis E virus genotype 3 in shellfish, United Kingdom,” Emerging Infectious Diseases, vol. 18, pp. 2085–2087, 2012.
  34. M. Díez-Valcarce, P. Kokkinos, K. Söderberg, et al., “Occurrence of human enteric viruses in commercial mussels at retail level in three European countries,” Food and Environmental Virology, vol. 4, pp. 73–80, 2012.
  35. I. Di Bartolo, M. Díez-Valcarce, P. Vasickova, et al., “Hepatitis E virus in pork production chain in Czech Republic, Italy, and Spain, 2010,” Emerging Infectious Diseases, vol. 18, pp. 1282–1289, 2012.
  36. A. R. Garbuglia, P. Scognamiglio, N. Petrosillo, et al., “Hepatitis E virus genotype 4 outbreak, Italy, 2011,” Emerging Infectious Diseases, vol. 19, pp. 110–114, 2013.
  37. M. Fogeda, A. Avellón, and J. M. Echevarría, “Prevalence of specific antibody to hepatitis E virus in the general population of the community of Madrid, Spain,” Journal of Medical Virology, vol. 84, no. 1, pp. 71–74, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Bendall, V. Ellis, S. Ijaz, R. Ali, and H. Dalton, “A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries,” Journal of Medical Virology, vol. 82, no. 5, pp. 799–805, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. J.-M. Mansuy, R. Bendall, F. Legrand-Abravanel et al., “Hepatitis E virus antibodies in blood donors, France,” Emerging Infectious Diseases, vol. 17, no. 12, pp. 2309–2312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Rossi-Tamisier, V. Moal, R. Gerolami, and P. Colson, “Discrepancy between anti-hepatitis E virus immunoglobulin G prevalence assessed by two assays in kidney and liver transplant recipients,” Journal of Clinical Virology, vol. 56, pp. 62–64, 2013.
  41. W. Bernal, H. M. Smith, and R. Williams, “A community prevalence study on antibodies to hepatitis A and E in inerr-city London,” Journal of Medical Virology, vol. 49, pp. 230–234, 1996.
  42. T. Redlinger, K. O'Rourke, L. Nickey, and G. Martinez, “Elevated hepatitis A and E seroprevalence rates in a Texas/Mexico border community,” Texas Medicine, vol. 94, no. 5, pp. 68–71, 1998. View at Scopus
  43. C.-C. Huang, D. Nguyen, J. Fernandez et al., “Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV),” Virology, vol. 191, no. 2, pp. 550–558, 1992. View at Publisher · View at Google Scholar · View at Scopus
  44. J. M. Echevarría, J. E. González, L. L. Lewis-Ximénez, et al., “Hepatitis E virus infection in Latin America: a review,” Journal of Medical Virology, vol. 85, pp. 1037–1045, 2013.
  45. E. E. Mast, I. Ken Kuramoto, M. O. Favorov et al., “Prevalence of and risk factors for antibody to hepatitis E virus seroreactivity among blood donors in Northern California,” Journal of Infectious Diseases, vol. 176, no. 1, pp. 34–40, 1997. View at Scopus
  46. C. Xu, R. Y. Wang, C. A. Schechterly, et al., “assessment of hepatitis E virus (HEV) in US blood donors and recipients: no detectable HEV RNA in 1939 donors tested and no evidence for HEV transmission to 362 prospectively followed recipients,” Transfusion, vol. 53, no. 10, pp. 2505–2511, 2013. View at Publisher · View at Google Scholar
  47. A. Cleland, L. Smith, C. Crossan, et al., “Hepatitis E virus in Scottish blood donors,” Vox Sanguinis, vol. 105, no. 4, pp. 283–289, 2013.
  48. A. Boutrouille, L. Bakkali-Kassimi, C. Crucière, and N. Pavio, “Prevalence of anti-hepatitis E virus antibodies in French blood donors,” Journal of Clinical Microbiology, vol. 45, no. 6, pp. 2009–2010, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. P. León, E. Venegas, L. Bengoechea, et al., “Prevalencia de las infecciones producidas por los virus de la hepatitis B, C, D y E en distintas poblaciones de Bolivia,” Revista Panamericana de Salud Pública, vol. 5, pp. 144–151, 1999.
  50. F. H. Pujol, M. O. Favorov, T. Marcano et al., “Prevalence of antibodies against hepatitis E virus among urban and rural populations in Venezuela,” Journal of Medical Virology, vol. 42, no. 3, pp. 234–236, 1994. View at Scopus
  51. L. Blitz-Dorfman, F. Monsalve, R. Atencio et al., “Serological survey of markers of infection with viral hepatitis among the Yukpa Amerindians from western Venezuela,” Annals of Tropical Medicine and Parasitology, vol. 90, no. 6, pp. 655–657, 1996. View at Scopus
  52. A. N. De Silva, A. K. Muddu, J. P. Iredale, N. Sheron, S. I. Khakoo, and E. Pelosi, “Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: time for routine testing?” Journal of Medical Virology, vol. 80, no. 2, pp. 283–288, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. J. M. Echevarría, M. Fogeda, and A. Avellón, “Update of cases of acute hepatitis E confirmed by the National Centre of Microbiology (Spain, 2004–2011),” Enfermedades Infecciosas y Microbiología Clínica, vol. 31, pp. 57–61, 2013.
  54. S. U. Emerson, V. A. Arankalle, and R. H. Purcell, “Thermal stability of hepatitis E virus,” Journal of Infectious Diseases, vol. 192, no. 5, pp. 930–933, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Schielke, M. Filter, B. Appel, and R. Johne, “Thermal stability of hepatitis e virus assessed by a molecular biological approach,” Virology Journal, vol. 8, pp. 487–495, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. E. Barnaud, S. Rogée, P. Garry, N. Rose, and N. Pavio, “Thermal inactivation of infectious hepatitis E virus in experimentally contaminated food,” Applied and Environmental Microbiology, vol. 78, pp. 5153–5159, 2012.
  57. M. V. Murhekar, S. C. Sehgal, K. M. Murhekar, S. P. Padbhidri, S. D. Chitambar, and V. A. Arankalle, “Changing scenario of hepatitis A virus and hepatitis E virus exposure among the primitive tribes of Andaman and Nicobar Islands, India over the 10-year period 1989-99,” Journal of Viral Hepatitis, vol. 9, no. 4, pp. 315–321, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. C. H. Hau, T. T. Hien, N. T. K. Tien et al., “Prevalence of enteric hepatitis A and E viruses in the Mekong River delta region of Vietnam,” The American Journal of Tropical Medicine and Hygiene, vol. 60, no. 2, pp. 277–280, 1999. View at Scopus
  59. J. Lu, Y. Zhou, X. Lin et al., “General epidemiological parameters of viral hepatitis A, B, C, and E in six regions of China: a cross-sectional study in 2007,” PLoS ONE, vol. 4, no. 12, Article ID e8467, 2009. View at Scopus
  60. K. H. Wong, Y. M. Liu, P. S. P. Ng, B. W. Y. Young, and S. S. Lee, “Epidemiology of hepatitis A and hepatitis E infection and their determinants in adult Chinese community in Hong Kong,” Journal of Medical Virology, vol. 72, no. 4, pp. 538–544, 2004. View at Publisher · View at Google Scholar · View at Scopus
  61. A. Quintana, L. Sanchez, O. Larralde, and D. Anderson, “Prevalence of antibodies to hepatitis E virus in residents of a district in Havana, Cuba,” Journal of Medical Virology, vol. 76, no. 1, pp. 69–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. O. Wichmann, S. Schimanski, J. Koch et al., “Phylogenetic and case-control study on hepatitis E virus infection in Germany,” Journal of Infectious Diseases, vol. 198, no. 12, pp. 1732–1741, 2008. View at Publisher · View at Google Scholar · View at Scopus
  63. H. C. Lewis, S. Boisson, S. Ijaz et al., “Hepatitis E in England and Wales,” Emerging Infectious Diseases, vol. 14, no. 1, pp. 165–167, 2008. View at Scopus
  64. G. Gessoni and F. Manoni, “Hepatitis E virus infection in north-east Italy: serological study in the open population and groups at risk,” Journal of Viral Hepatitis, vol. 3, no. 4, pp. 197–202, 1996. View at Scopus
  65. A. Vulcano, M. Angelucci, E. Candelori et al., “HEV prevalence in the general population and among workers at zoonotic risk in Latium Region,” Annali di igiene, vol. 19, no. 3, pp. 181–186, 2007. View at Scopus
  66. M. Rapicetta, L. A. Kondili, S. Pretolani, et al., “Seroprevalence and anti-HEV persistence in the general population of the Republic of San Marino,” Journal of Medical Virology, vol. 58, pp. 49–53, 1999.
  67. M. Buti, A. Domínguez, P. Plans, et al., “Community-based seroepidemiological survey of hepatitis E virus infection in Catalonia, Spain,” Clinical and Vaccine Immunology, vol. 13, pp. 1328–1332, 2006.
  68. M. Buti, P. Plans, A. Domínguez et al., “Prevalence of hepatitis E virus infection in children in the northeast of Spain,” Clinical and Vaccine Immunology, vol. 15, no. 4, pp. 732–734, 2008. View at Publisher · View at Google Scholar · View at Scopus
  69. M. S. Faber, J. J. Wenzel, W. Jilg, M. Thamm, M. Höhle, and K. Stark, “Hepatitis E virus seroprevalence among adults, Germany,” Emerging Infectious Diseases, vol. 18, pp. 1654–1657, 2012.
  70. P. Mathur, N. K. Arora, S. K. Panda, S. K. Kapoor, B. L. Jailkhani, and M. Irshad, “Sero-epidemiology of Hepatitis E virus (HEV) in urban and rural children of North India,” Indian Pediatrics, vol. 38, no. 5, pp. 461–475, 2001. View at Scopus
  71. B. Mohanavalli, E. Dhevahi, T. Menon, S. Malathi, and S. P. Thyagarajan, “Prevalence of antibodies to Hepatitis A and Hepatitis E virus in urban school children in Chennai,” Indian Pediatrics, vol. 40, no. 4, pp. 328–331, 2003. View at Scopus
  72. R. Vivek, G. M. Chandy, D. W. Brown, and G. Kang, “Seroprevalence of IgG antibodies to hepatitis E in urban and rural southern India,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 104, no. 4, pp. 307–308, 2010. View at Publisher · View at Google Scholar · View at Scopus
  73. W. Jafri, J. Yakoob, S. Abid, et al., “Seroprevalence of hepatitis E and Helicobacter pylori in a low socioeconomic area of a metropolitan city in a developing country,” British Journal of Biomedical Science, vol. 70, pp. 27–30, 2013.
  74. S. Hinjoy, K. E. Nelson, R. V. Gibbons et al., “A cross-sectional study of hepatitis E virus infection in healthy people directly exposed and unexposed to pigs in a rural community in Northern Thailand,” Zoonoses and Public Health, vol. 60, no. 8, pp. 555–562, 2013. View at Publisher · View at Google Scholar
  75. H. F. Seow, N. M. B. Mahomed, J.-W. Mak, M. A. Riddell, F. Li, and D. A. Anderson, “Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia,” Journal of Medical Virology, vol. 59, pp. 164–168, 1999.
  76. I. D. N. Wibawa, D. H. Muljono, M. Mulyanto et al., “Prevalence of antibodies to hepatitis E virus among apparently healthy humans and pigs in Bali, Indonesia: identification of A pig infected with A genotype 4 hepatitis E virus,” Journal of Medical Virology, vol. 73, no. 1, pp. 38–44, 2004. View at Publisher · View at Google Scholar · View at Scopus
  77. R.-C. Li, S.-X. Ge, Y.-P. Li et al., “Seroprevalence of hepatitis E virus infection, rural southern People's Republic of China,” Emerging Infectious Diseases, vol. 12, no. 11, pp. 1682–1688, 2006. View at Scopus
  78. Y.-S. Yan, H.-R. Wang, L.-L. Wang et al., “A sero-epidemiology study on hepatitis E virus infection in Fujian province,” Zhonghua liu xing bing xue za zhi, vol. 28, no. 2, pp. 105–108, 2007. View at Scopus
  79. B. Lu, H. L. Zhao, R. G. Tian et al., “Antibody detection of hepatitis E virus in human population of different national in China,” Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, vol. 26, pp. 46–47, 2012.
  80. D. M. Y. Chiu, M. C. W. Chan, A. C. M. Yeung, K. L. K. Ngai, and P. K. S. Chan, “Seroprevalence of hepatitis E virus in Hong Kong, 2008-2009,” Journal of Medical Virology, vol. 85, pp. 459–461, 2013.
  81. S.-D. Lee, Y.-J. Wang, R.-H. Lu, C.-Y. Chan, K.-J. Lo, and R. Moeckli, “Seroprevalence of antibody to hepatitis E virus among Chinese subjects in Taiwan,” Hepatology, vol. 19, no. 4, pp. 866–870, 1994. View at Publisher · View at Google Scholar · View at Scopus
  82. C.-F. Peng, M.-R. Lin, P.-Y. Chue et al., “Prevalence of antibody to hepatitis E virus among healthy individuals in Southern Taiwan,” Microbiology and Immunology, vol. 39, no. 9, pp. 733–736, 1995. View at Scopus
  83. D.-B. Lin, J.-B. Lin, S.-C. Chen, C.-C. Yang, W.-K. Chen, and C.-J. Chen, “Seroepidemiology of hepatitis E virus infection among preschool children in Taiwan,” Journal of Medical Virology, vol. 74, no. 3, pp. 414–418, 2004. View at Publisher · View at Google Scholar · View at Scopus
  84. E. Tanaka, N. Takeda, T.-C. Li et al., “Seroepidemiological study of hepatitis E virus infection in Japan using a newly developed antibody assay,” Journal of Gastroenterology, vol. 36, no. 5, pp. 317–321, 2001. View at Publisher · View at Google Scholar · View at Scopus
  85. M. Takahashi, K. Tamura, Y. Hoshino et al., “A nationwide survey of hepatitis E virus infection in the general population of Japan,” Journal of Medical Virology, vol. 82, no. 2, pp. 271–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. H. K. Park, S.-H. Jeong, J.-W. Kim, B.-H. Woo, D. H. Lee, and H. Y. Kim, “Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays,” BMC Infectious Diseases, vol. 12, pp. 142–147, 2012.
  87. D. L. Thomas, R. W. Mahley, S. Badur, E. Palaoglu, and T. C. Quinn, “The epidemiology of hepatitis C in Turkey,” Infection, vol. 22, no. 6, pp. 411–414, 1994. View at Publisher · View at Google Scholar · View at Scopus
  88. M. Sidal, E. Ünüvar, F. Ouz, C. Cihan, D. Önel, and S. Badur, “Age-specific seroepidemiology of hepatitis A, B, and E infections among children in Istanbul, Turkey,” European Journal of Epidemiology, vol. 17, no. 2, pp. 141–144, 2001. View at Publisher · View at Google Scholar · View at Scopus
  89. D. Colak, D. Ogunc, F. Gunseren, S. Velipasaoglu, M. R. Aktekin, and M. Gultekin, “Seroprevalence of antibodies to hepatitis A and E viruses in pediatric aGe groups in Turkey,” Acta Microbiologica et Immunologica Hungarica, vol. 49, no. 1, pp. 93–97, 2002. View at Publisher · View at Google Scholar · View at Scopus
  90. A. S. Cevrioglu, M. Altindis, H. M. Tanir, and F. Aksoy, “Investigation of the incidence of hepatitis E virus among pregnant women in Turkey,” Journal of Obstetrics and Gynaecology Research, vol. 30, no. 1, pp. 48–52, 2004. View at Publisher · View at Google Scholar · View at Scopus
  91. S. Oncu, S. Oncu, P. Okyay, S. Ertug, and S. Sakarya, “Prevalence and risk factors for HEV infection in pregnant women,” Medical Science Monitor, vol. 12, no. 1, pp. CR36–CR39, 2006. View at Scopus
  92. A. D. Kaya, C. E. Ozturk, T. Yavuz, C. Ozaydin, and T. Bahcebasi, “Changing patterns of hepatitis A and E sero-prevalences in children after the 1999 earthquakes in Duzce, Turkey,” Journal of Paediatrics and Child Health, vol. 44, no. 4, pp. 205–207, 2008. View at Publisher · View at Google Scholar · View at Scopus
  93. A. Eker, Ö. Tansel, H. Kunduracilar, B. Tokuç, Z. Yuluǧkural, and P. Yüksel, “Hepatitis e virus epidemiology in adult population in edirne province, Turkey,” Mikrobiyoloji Bulteni, vol. 43, no. 2, pp. 251–258, 2009. View at Scopus
  94. M. Taremi, A. H. Mohammad Alizadeh, A. Ardalan, S. Ansari, and M. R. Zali, “Seroprevalence of hepatitis E in Nahavand, Islamic Republic of Iran: a population-based study,” Eastern Mediterranean Health Journal, vol. 14, no. 1, pp. 157–162, 2008. View at Scopus
  95. B. Ataei, Z. Nokhodian, A. A. Javadi et al., “Hepatitis E virus in Isfahan Province: a population-based study,” International Journal of Infectious Diseases, vol. 13, no. 1, pp. 67–71, 2009. View at Publisher · View at Google Scholar · View at Scopus
  96. M. J. Saffar, R. Farhadi, A. Ajami, A. R. Khalilian, F. Babamahmodi, and H. Saffar, “Seroepidemiology of hepatitis E virus infection in 2-25-year-olds in Sari district, Islamic Republic of Iran,” Eastern Mediterranean Health Journal, vol. 15, no. 1, pp. 136–142, 2009. View at Scopus
  97. R. H. Raoofi, M. R. Nazer, and Y. Pournia, “Seroepidemiology of hepatitis E virus in Western Iran,” Brazilian Journal of Infectious Diseases, vol. 16, pp. 302–303, 2012.
  98. S. R. Mohebbia, M. R. Nejada, S. M. E. Tahaeia, et al., “Seroepidemiology of hepatitis A and E virus infections in Tehran, Iran: a population based Study,” Transactions of the Royal Society of Tropica Medicine and Hygiene, vol. 106, pp. 528–531, 2012.
  99. A. A. Bawazir, C. A. Hart, T. A. Sallam, C. M. Parry, N. J. Beeching, and L. E. Cuevas, “Seroepidemiology of hepatitis A and hepatitis E viruses in Aden, Yemen,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 104, no. 12, pp. 801–805, 2010. View at Publisher · View at Google Scholar · View at Scopus
  100. Y. V. Karetnyi, M. O. Favorov, N. S. Khudyakova et al., “Serological evidence for hepatitis E virus infection in Israel,” Journal of Medical Virology, vol. 45, no. 3, pp. 316–320, 1995. View at Publisher · View at Google Scholar · View at Scopus
  101. A. D. Fix, M. Abdel-Hamid, R. H. Purcell et al., “Prevalence of antibodies to hepatitis E in two rural Egyptian communities,” The American Journal of Tropical Medicine and Hygiene, vol. 62, no. 4, pp. 519–523, 2000. View at Scopus
  102. A. A. Aboulata, M. S. Ahmad, M. M. A. Shaban, K. M. S. Zayd, and A. M. Abd El-Moktader, “Prevalence of hepatitis E virus in Egyptian children presented with minor hepatic disorders,” The Egyptian Journal of Immunology, vol. 12, no. 2, pp. 71–76, 2005. View at Scopus
  103. G. Y. Minuk, A. Sun, D. F. Sun et al., “Serological evidence of hepatitis E virus infection in an indigenous North American population,” Canadian Journal of Gastroenterology, vol. 21, no. 7, pp. 439–442, 2007. View at Scopus
  104. B. C. A. Langer, G. G. Frösner, and A. Von Brunn, “Epidemiological study of viral hepatitis types A, B, C, D and E among Inuits in West Greenland,” Journal of Viral Hepatitis, vol. 4, no. 5, pp. 339–349, 1997. View at Scopus
  105. O. M. Perez, W. Morales, M. Paniagua, and O. Strannegard, “Prevalence of antibodies to hepatitis A, B, C, and E viruses in a healthy population in Leon, Nicaragua,” The American Journal of Tropical Medicine and Hygiene, vol. 55, no. 1, pp. 17–21, 1996. View at Scopus
  106. J. A. Rey, J. A. Findor, J. R. Daruich et al., “Prevalence of IgG anti-HEV in Buenos Aires, a nonendemic area for hepatitis E,” Journal of Travel Medicine, vol. 4, no. 2, pp. 100–101, 1997. View at Publisher · View at Google Scholar · View at Scopus
  107. H. Ibarra, S. Riedemann, G. Reinhardt, et al., “Hepatitis A and E virus antibodies in Chilean children of low socioeconomic status: a one year follow-up study,” Revista Medica de Chile, vol. 134, no. 2, pp. 139–144, 2006. View at Scopus
  108. H. Ibarra, S. Riedemann, G. Reinhardt, et al., “Anti-HEV marker in blood donors and other population groups in Southern Chile,” Revista Medica de Chile, vol. 125, no. 3, pp. 275–278, 1997. View at Scopus
  109. A. Bartoloni, F. Bartalesi, M. Roselli et al., “Prevalence of antibodies against hepatitis A and E viruses among rural populations of the Chaco region, south-eastern Bolivia,” Tropical Medicine and International Health, vol. 4, no. 9, pp. 596–601, 1999. View at Publisher · View at Google Scholar · View at Scopus
  110. M. T. Álvarez-Muñoz, J. Torres, L. Damasio, A. Gómez, R. Tapia-Conyer, and O. uñoz, “Seroepidemiology of hepatitis E virus infection in Mexican subjects 1 to 29 years of age,” Archives of Medical Research, vol. 30, pp. 251–254, 1999.
  111. S. B. Assis, F. J. D. Souto, C. J. F. Fontes, and A. M. C. Gaspar, “Prevalence of hepatitis A and E virus infection in school children of an Amazonian municipality in Mato Grosso State,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 35, no. 2, pp. 155–158, 2002. View at Scopus
  112. M. C. M. Villalba, M. Guan, A. Pérez et al., “Seroprevalence of antibodies to hepatitis E virus in two large communities in Havana, Cuba,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 104, no. 12, pp. 772–776, 2010. View at Publisher · View at Google Scholar · View at Scopus
  113. H. Ibarra, G. S. Riedemann, V. G. Reinhardt, and A. M. Calvo, “Presence of anti hepatitis E virus antibodies in swine: is it an animal reservoir for hepatitis E?” Revista Medica de Chile, vol. 135, no. 8, pp. 997–1001, 2007. View at Scopus
  114. H. Fainboim, J. González, E. Fassio et al., “Prevalence of hepatitis viruses in an anti-human immunodeficiency virus-positive population from Argentina. A multicentre study,” Journal of Viral Hepatitis, vol. 6, no. 1, pp. 53–57, 1999. View at Scopus
  115. G. Lemos, S. Jameel, S. Panda, L. Rivera, L. Rodríguez, and J. V. Gavilondo, “Hepatitis E virus in Cuba,” Journal of Clinical Virology, vol. 16, no. 1, pp. 71–75, 2000. View at Publisher · View at Google Scholar · View at Scopus
  116. A. L. Bortoliero, A. M. Bonametti, H. K. Morimoto, T. Matsuo, and E. M. V. Reiche, “Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil,” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 48, no. 2, pp. 87–92, 2006. View at Scopus
  117. L. Queirós, J. Condeço, A. Tender, M. Mateus, A. Teixeira, and H. Pascoal, “The seroprevalence for hepatitis E viral antibodies in the northern region of Portugal (among the donor population),” Acta Médica Portuguesa, vol. 10, pp. 447–453, 1997.
  118. M. L. Mateos, C. Camarero, E. Lasa, J. L. Teruel, N. Mir, and F. Baquero, “Hepatitis E virus: relevance in blood donors and risk groups,” Vox Sanguinis, vol. 76, no. 2, pp. 78–80, 1999. View at Scopus
  119. D. Juhl, S. A. Baylis, J. Blümel, S. Görg, and H. Hennig, “Seroprevalence and incidence of hepatitis E virus infection in German blood donors,” Transfusion, vol. 54, no. 1, pp. 49–56, 2014.
  120. Q.-S. Guo, Q. Yan, J. H. Xiong, et al., “Prevalence of hepatitis E virus in Chinese blood donors,” Journal of Clinical Microbiology, vol. 48, pp. 317–318, 2010.
  121. H. Takeda, K. Matsubayashi, H. Sakata et al., “A nationwide survey for prevalence of hepatitis E virus antibody in qualified blood donors in Japan,” Vox Sanguinis, vol. 99, no. 4, pp. 307–313, 2010. View at Publisher · View at Google Scholar · View at Scopus