Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury

Figure 2

Fgf7 and Fgf10 signaling via Fgfr2b controls proliferation versus chemotaxis, respectively. (a)–(c) Mesenchyme-free epithelium from E11.5 lungs was grown for 48 hours in Matrigel in absence (a) or presence of Fgf7 (b) or Fgf10 (c). Note the formation of a cyst-like structure with Fgf7 versus distinct primary and secondary bud formation with Fgf10. (d), (e) Proposed model for Fgf7 versus Fgf10 action via Fgfr2b according to [20]. (d) Fgf7 induces transient signaling and Fgfr2b degradation leading to proliferation. (e) Fgf10 leads to sustained signaling which is associated with Fgfr2b recycling, phosphorylation of Y734 of Fgfr2b, and recruitment of p85/p110/SH3bp4 complex leading to chemotaxis.