Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury
Figure 5
Fgf10-positive cells represent a population of mesenchymal progenitors. (a) Fgf10 lacZ cells at E12.5 are located in the distal lung mesenchyme. (b) Model for the formation of the parabronchial smooth muscle cells. Fgf10-positive cells are amplified and then they differentiate as they relocate proximally (From [33]). (c) Lineage tracing of Fgf10-positive cells at E11.5 and E15.5 show that these cells are progenitors for multiple lineages and they become progressively restricted in their differentiation potential (From [34]).
