Summary of secondary pharmacodynamic concerns that are peculiar to phage- or protein-based antibacterial therapy. Issues are listed in brown at the corners of the figure, with more specific considerations listed in blue. Means by which these issues can be mitigated are presented as green blocks of text as found between concerns and the indication of “Side effects” shown in the center. Thus, for example, the issue of bacterial lysis products in phage formulations may be mitigated through a combination of informed bacterial choice in some combination with sufficient post-lysis purification of resulting phages.
