Review Article

Phage Therapy: Eco-Physiological Pharmacology

Table 1

Studies involving phage-mediated biocontrol and therapy of bacteria from approximately the first six months of 2013.

TargetContextClassification*References

Clostridium difficile In vitro colon modelTherapy[228]
Escherichia coli BeefBiocontrol[229]
Escherichia coli Chickens (colibacillosis)Therapy[230]
Escherichia coli Milk (during fermentation)Biocontrol[231]
Escherichia coli BeefBiocontrol[232]
Escherichia coli VegetablesBiocontrol[233, 234]
Mycobacterium ulcerans Mouse footpad modelTherapy[235]
Pectobacterium carotovorum LettuceBoth[236]
Pseudomonas aeruginosa In vitro and tooth biofilm modelsTherapy[237]
Pseudomonas aeruginosa In vitro biofilm modelBiocontrol[238, 239]
Salmonella enterica Chicken skin (food)Biocontrol[240]
Salmonella enterica EggsBiocontrol[241]
Salmonella enterica Various foodsBiocontrol[242]
Salmonella gallinarum ChickensTherapy[243]
Shigella spp.Chicken (food)Biocontrol[244]
Staphylococcus aureus Rabbit wound modelTherapy[151]
Staphylococcus aureus Mouse diabetic foot modelTherapy[245]
Staphylococcus aureus Rat implant modelTherapy[223]
Vibrio cholerae Rabbit modelTherapy[246]
Vibrio coralliilyticus CoralBoth[247]

Classification is based on the discussion of Abedon [78]. Generally, “therapy” involves treatment of disease in infected or potentially infected individuals; that is, therapy thus is both of infectious, bacteria-caused disease and of an individual disease-carrying host. “Biocontrol” by contrast involves treatment of environments, variously defined. Therapy also can be viewed as phage use as a drug or especially antibiotic equivalent whereas biocontrol, narrowly defined, is phage use as a disinfectant or antiseptic equivalent. “Both” refers to treatments that could be classified as either biocontrol or therapy because individuals are being treated within the context of the treatment of environments such as the use of phages in agriculture against plant pathogens. In either case, treatment versus prevention is not distinguished in the table.