The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure
Figure 2
Circulating hydrogen sulfide levels are diminished in heart failure patients. We evaluated H2S levels in heart failure patients () compared to age-matched control subjects (). Serum free H2S (μM) levels were significantly reduced () in heart failure patients. Serum samples were obtained from patients enrolled in the Atlanta Cardiomyopathy Consortium (TACC). This prospective cohort study enrolls patients from the Emory University-affiliated teaching hospitals, the Emory University Hospital and Emory University Hospital Midtown, and Grady Memorial Hospital in Atlanta. All patients undergo detailed medical history surveys, electrocardiogram, standardized questionnaires, and blood and urine sample collection at baseline. All patients provide written informed consent prior to enrollment. The Emory University Institutional Review Board has approved this study. H2S levels were measured in the blood according to previously described methods [20].
