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Scientifica
Volume 2014 (2014), Article ID 970315, 8 pages
http://dx.doi.org/10.1155/2014/970315
Review Article

Human Interferon Alpha-2b: A Therapeutic Protein for Cancer Treatment

Research Center for Biotechnology, Cibinong Science Center, Jalan Raya Bogor km 46, Cibinong, Bogor, West Java 16911, Indonesia

Received 3 January 2014; Accepted 22 January 2014; Published 10 March 2014

Academic Editors: A. Asai and A. Espinosa

Copyright © 2014 Ratih Asmana Ningrum. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human interferon alpha (hIFN ) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. It regulates many genes that are involved in antiviral and antiproliferative activities. This mini review focuses on human interferon alpha-2b (hIFN -2b) as therapeutic protein for cancer treatment. The review covers hIFN -2b molecular characteristic and its molecular mechanism by Janus activated kinase/signal transducer activation of transcription (JAK-STAT) pathway. The JAK-STAT pathway regulates not only proteins involved in inhibition of proliferation but also apoptosis. As additional discussion of clinical applications, the use of recombinant hIFN -2b (rhIFN -2b) as therapeutic protein in several types of cancer is also explained.