| MicroRNA cluster | Chromosome | MicroRNAs | Biological functions | Oncogenic role |
| miR-17-92 | 13 | miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1 | Angiogenesis [51, 104] Apoptosis [47, 105, 106] B cell development [38, 42, 107] Cell cycle progression [47, 105, 106] Development of lung, heart, kidney, cerebral hemisphere, small intestine, submandibular salivary gland, and tooth germ [41, 42, 108] Enhanced proliferation [42, 44, 85] Inhibited differentiation [59] | Expression in human: Colon cancers ↑ [56] Lung cancers ↑ [44, 59] Lymphomas ↑ [47] Solid tumors ↑ [40] Thyroid cancers ↑ [109, 110] Tumor angiogenesis [51, 104] |
| miR-106a-363 | X | miR-106a, miR-18b, miR-19b-2, miR-20b, miR-92a-2, and miR-363 | Aging [111] Angiogenesis [78] Apoptosis [112] Cellular growth [79, 85] Development of lung and heart [84] | Expression in human: Ewing sarcoma tumors ↓ [113] Head and neck cancers ↓ [75] Oral cancers ↓ [85] T cell leukemia ↑ [32] |
| miR-106b-25 | 7 | miR-106b, miR-93, and miR-25 | Apoptosis [87] Cell cycle progression [32] Proliferation and differentiation [94] | Expression in human: Esophageal cancers ↑ [89] Gastric cancers ↑ [87] Hepatocellular tumors ↑ [88] Prostate cancers ↑ [32] |
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