Is Gastroparesis Found More Frequently in Patients with Cystic Fibrosis? A Systematic Review

Table 1

Studies evaluating gastric emptying in cystic fibrosis.

Author	Year	Location	Subjects			Gender		Age		DM		Pancreatic insufficiency		Intervention	Result
						Male		Mean
			CF	Controls	Total	CF	Controls	CF	Controls	CF	Controls	CF	Controls
⁢Capsule methods
Hedsund et al. [14]	2012	Denmark	10	16	26	5	9	23	26	0	0	10	0	No	No difference
Gelfond et al. [15]	2013	Buffalo, NY	10	10	20	3	3	21.7	22.5	0	0	10	0	No	No difference
⁢C-Octanoic breath test
De Boeck et al. [5]	1998	Belgium	11	—	11	4	—	10.5	—	—	—	11	—	Creon and high-lipase Creon in CF.	No control group
Symonds et al. [9]	2003	Australia	10	12	22	5	7	10.2	12.5	NA	0	10	0	Pancreas in CF	No difference
Neumann et al. [16]	2003	Czech Republic	20	—	20	NA	—	13.5	—	—	—	—	—	No	No difference
Hauser et al. [17]	2010	Belgium	19	—	19	13	—	5	—	—	—	—	—	No	No control group
Pauwels et al. [18]	2011	Belgium	33	—	33	18	—	28	—	0	—	31	—	No	No control group
Hauser et al. [19]	2013	Belgium	22	—	22	12	—	9	—	—	—	0	—	No	No control group
⁢Scintigraphy with technetium
Davidson et al. [20]	1995	Canada	70	—	70	NA	—	NA	—	—	—	—	—	No	No control group
Carney et al. [21]	1995	Australia	5	11	16	3	4	25	21	0	0	5	0	No	CF Faster
Collins et al. [22]	1997	Australia	19	17	36	8	8	12.6	12.8	2	0	19	0	Usual dose of PERT in CF	CF Faster
Munck et al. [23]	1997	France	7	—	7	NA	—	NA	—	—	—	—	—	Erythromycin in CF	No control group
Couturier et al. [24]	2004	France	48	53	101	NA	42	NA	31.84	NA	0	NA	0	No	CF Slower
King et al. [25]	2006	Australia	22	—	22	8	—	NA	—	—	—	18	—	Usual dose of PERT in CF	No control group
Tonelli et al. [26]	2009	Gainesville, FL	5	—	5	1	—	25.2	—	2	—	5	—	IV Erythromycin in CF	No control group
Luu et al. [27]	2011	Canada	17	—	17	NA	—	NA	—	—	—	—	—	Measurements before and after Cisapride in CF	No control group
Kuo et al. [28]	2011	Australia	5	6	11	3	3	25.8	21.7	0	0	5	6	Creon versus Placebo in CF	CF Faster
Mendez et al. [29]	2012	Chicago, Il	10	78	88	8	38	28	59	NA	NA	NA	NA	No	CF Slower
Rovner et al. [4]	2013	Philadelphia, PA	16	12	28	9	6	16.7	28.6	0	0	16	0	Creon in CF	No difference
			359	215	574	100 (50.76%)	120 (55.81%)			4 (5.71%)	0 (0.00%)	140 (84.85%)	6 (4.38%)

Of available data.
CF: cystic fibrosis and NA: data not available.