Development and Characterization of Novel Floating-Mucoadhesive Tablets Bearing Venlafaxine Hydrochloride

Table 6

Physiochemical characterization of venlafaxine hydrochloride tablets.

Code	% weight variation	Hardness (kg/cm^2)	% friability	% drug content uniformity	Floating lag time (sec)	Total floating time (hr)
FC1	±3.0%	6.40 ± 0.16	0.524	99.21 ± 1.46	112 ± 2.87	17.33 ± 2.05
FC2	±4.5%	6.37 ± 0.45	0.564	98.47 ± 0.34	99 ± 2.49	18.50 ± 1.87
FC3	±3.5%	6.53 ± 0.57	0.572	98.86 ± 1.24	88 ± 2.87	23.33 ± 0.62
FC4	±4.0%	6.63 ± 0.58	0.482	97.20 ± 0.18	74 ± 3.27	27.08 ± 0.95
FC5	±2.5%	6.93 ± 0.52	0.458	98.53 ± 0.52	94 ± 3.27	12.75 ± 2.08
FC6	±3.0%	6.70 ± 0.70	0.545	99.08 ± 2.21	82 ± 2.94	26.50 ± 1.02
FC7	±4.0%	6.43 ± 0.33	0.584	97.40 ± 1.02	76 ± 2.45	29.25 ± 0.74
FC8	±4.0%	6.67 ± 0.98	0.580	98.91 ± 0.18	72 ± 2.49	24.50 ± 0.74
FC9	±2.5%	6.70 ± 0.49	0.495	98.00 ± 0.24	64 ± 2.94	26.50 ± 1.54
FC10	±3.0%	6.47 ± 0.90	0.457	97.56 ± 1.32	54 ± 2.45	26.25 ± 1.87
FC11	±3.0%	6.80 ± 0.43	0.530	98.43 ± 0.64	67 ± 3.74	28.25 ± 0.69
FC12	±4.5%	6.27 ± 0.41	0.572	99.02 ± 1.45	81 ± 2.87	20.52 ± 0.92
FC13	±4.5%	6.67 ± 0.66	0.592	98.74 ± 0.82	93 ± 3.27	18.00 ± 0.82

Mean ± SD; ; FC: formulation code.