Development and Characterization of Novel Floating-Mucoadhesive Tablets Bearing Venlafaxine Hydrochloride

Table 9

Stability studies of venlafaxine hydrochloride floating tablets of optimized formulation (FC8).

Characteristic	Initial	1st month	2nd month	3rd month
Hardness (kg/cm^2)	6.67 ± 0.98	6.02 ± 0.56	6.42 ± 0.20	6.30 ± 0.88
Drug content (%)	98.91 ± 0.18	98.34 ± 0.02	98.12 ± 1.42	98.00 ± 0.27
Floating lag time (seconds)	72 ± 2.65	76 ± 1.26	84 ± 2.45	90 ± 3.26
Total floating time (hours)	24.50 ± 0.74	24.16 ± 1.12	24.18 ± 2.26	24.08 ± 0.34
Swelling index (%)	161.52	160.82	160.64	160.18
Buoyancy on disturbing	Float	Float	Float	Float
Matrix integrity	Very good	Very good	Very good	Very good
% in vitro release 18 hours	96.92 ± 0.83	94.43 ± 1.38	93.98 ± 0.42	93.00 ± 1.56

Mean ± SD; ; FC: formulation code.