In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin

Table 1

Composition of empty niosomal formulations at various ratios of cholesterol : surfactant.

Sr. number	Formulation codes	Drug : cholesterol : surfactant	Dicetyl phosphate (DCP) (mg)	Surfactant grade
1	NA1	1 : 0.5 : 1	5.0	SPAN-20
2	NA2	1 : 1 : 1	5.0	SPAN-20
3	NA3	1 : 1.5 : 1	5.0	SPAN-20
4	NA4	1 : 1 : 0.5	5.0	SPAN-20
5	NA5	1 : 1 : 1.5	5.0	SPAN-20
6	NB1	1 : 0.5 : 1	5.0	SPAN-40
7	NB2	1 : 1 : 1	5.0	SPAN-40
8	NB3	1 : 1.5 : 1	5.0	SPAN-40
9	NB4	1 : 1 : 0.5	5.0	SPAN-40
10	NB5	1 : 1 : 1.5	5.0	SPAN-40
11	NC1	1 : 0.5 : 1	5.0	SPAN-60
12	NC2	1 : 1 : 1	5.0	SPAN-60
13	NC3	1 : 1.5 : 1	5.0	SPAN-60
14	NC4	1 : 1 : 0.5	5.0	SPAN-60
15	NC5	1 : 1 : 1.5	5.0	SPAN-60
16	ND1	1 : 0.5 : 1	5.0	SPAN-80
17	ND2	1 : 1 : 1	5.0	SPAN-80
18	ND3	1 : 1.5 : 1	5.0	SPAN-80
19	ND4	1 : 1 : 0.5	5.0	SPAN-80
20	ND5	1 : 1 : 1.5	5.0	SPAN-80