Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice

Figure 2

T. sinapou ethyl acetate extract inhibited both phases of formalin-induced overt pain-like behavior. Mice were treated with T. sinapou ethyl acetate extract (100 mg/kg, i.p., 30 min), morphine (5 mg/kg, i.p., 30 min), or vehicle before formalin injection. Total number of flinches of the first (panel (a)) and second (panel (b)) phases and time spent licking the paw of the first (panel (c)) and second (panel (d)) phases were evaluated at 0–5 min and 15–30 min intervals, respectively. Experiments were performed with 6 mice per group per experiment and are representative of 2 independent experiments. compared to the saline group, compared to the formalin + vehicle group.

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