Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption

Table 4

Analysis for the strength in the interaction of MDM2 protein after interaction with DHFR protein/MDM2-DHFR complex.

Parameters for strength in interaction	Before interaction	After interaction
Free energy of folding (kcal/mol)	−107.23; (MDM2 protein)	−218.7; (protein complex)
DFire (kcal/mol)	−249.79; (MDM2 protein)	−608.59; (protein complex)
Folding rate for MDM2 protein	1.43209/sec	2.08699/sec
Net area for solvent accessibility for MDM2 protein	7832.73 Å^2	5675.83 Å^2