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Paper | Design | n | % Male | Group | Intervention | Followup months | ΔBMI | ΔAHI | % With OSA cure |
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Johansson et al., 2011 [42] | Prospective cohort | 63 | 100 | BMI 30–40, AHI ≥ 15 | VLCD and weight maintenance programme | 12 | 35→31 | 36→19 | 10 |
Nerfeldt et al., 2010 [47] | Prospective cohort | 33 | 73% | BMI ≥ 30, AHI ≥ 10 and/or ODI ≥ 6, OSAS symptoms | LCD and behavioural change support | 24 | 40→35 | 43→28 | ? |
Johansson et al., 2009 [41] | Randomised, controlled, and parallel group | 63 | 100 | BMI 30–40, AHI ≥ 15 | VLCD | 2 | 34→29 v 35→35 | 37→12 v 37→35 | 17 v 0 |
Tuomilehto et al., 2009 [46] | Randomised, controlled, and parallel group | 72 | 74 | BMI 28–40 kg/m2, AHI 5–15 events/hr | VLCD, supervised lifestyle counselling | 12 | 33→? v 31→? | 10→6 v 9→10 | 63% v 35% |
Barnes et al., 2009 [45] | Cohort | 12 | 25 | BMI > 30 kg/m2, AHI 10–50 events/hr | VLCD and exercise programme | 12 | 36→30 | 25→18 | 0 |
Foster et al., 2009 [94] | Randomised, controlled, and parallel group | 264 | 41 | BMI ≥ 25 kg/m2, AHI ≥ 5 events/hr, type 2 diabetes | Intensive lifestyle intervention (diet/exercise) | 12 | 37→? v 37→? | 23→18 v 24→28 | 14 v 4 |
Kemppainen et al., 2008 [44] | Randomised, controlled, and parallel group | 52 | 79 | BMI 28–40 kg/m2, AHI 5–15 events/hr | VLCD, supervised lifestyle counselling | 3 | 33→? v 32→? | 11→8 v 9→8 | ? |
Kajaste et al., 2004 [48] | Cohort | 31 | 100 | BMI > 35 kg/m2, ODI > 10 events/hr | VLCD, CBT weight reduction program | 24 | 44→40 | 51→32 (ODI) | ? |
Kansanen et al., 1998 [40] | Prospective, cohort | 15 | 93 | Overweight with OSA | VLCD | 3 | 38→35 | 31→19 (ODI) | 20 |
Suratt et al., 1992 [39] | Cohort | 8 | 62 | Obese with OSA | VLCD | ? | 54→46 | 90→62 | ? |
Ferland et al., 2009 [56] | Nonrandomised, parallel group | 40 | 88 | BMI ≥ 30 kg/m2, OSAS | Sibutramine, diet and exercise v CPAP | 12 | 37→35 v 36→36 | 40→37 v 44→4 | ? |
Phillips et al., 2009 [55] | Cohort | 93 | 100 | BMI 30–38 kg/m2, RDI ≥ 15 events/hr | Sibutramine, diet and exercise | 6 | 34→32 | 46→30 (RDI) | ? |
Yee et al., 2007 [54] | Cohort | 87 | 100 | BMI 30–38 kg/m2, RDI ≥ 15 events/hr | Sibutramine, diet and exercise | 6 | 34→32 | 46→30 (RDI) | 5 |
Martinez and Basile, 2005 [53] | Randomised, double-blind, and controlled group | 19 | 100 | BMI 25–35 kg/m2, AHI ≥ 10 events/hr | Sibutramine v placebo | 1 | ? | 28→27 v 28→28 | ? |
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